Patients with reduced or preserved ejection fraction heart failure (HFrEF and HFpEF)
Relationships between the V̇E /V̇CO2 slope and both VD /VT and PaCO2surrogate
The physiological mechanisms driving exercise ventilatory inefficiency differ between heart failure phenotypes, with PaCO2 regulation dominating in HFrEF and increased dead space (VD/VT) dominating in HFpEF.
Relationships between the V̇E /V̇CO2 slope and both VD /VT and PaCO2 are robust, but differ between HFpEF and HFrEF. Increasing V̇E /V̇CO2 slope appears to be strongly explained by mechanisms influential in regulating PaCO2 in HFrEF, which contrasts with the strong role of increased VD /VT in HFpEF.
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Erik H. Van Iterson
Bruce D. Johnson
Barry A. Borlaug
European Journal of Heart Failure
Mayo Clinic in Arizona
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Iterson et al. (Sun,) studied this question.
www.synapsesocial.com/papers/69e1c7a43e490517ce86b74c — DOI: https://doi.org/10.1002/ejhf.913