March 31, 2017
View Full PaperInfluence of Left Atrial Function on Exercise Capacity and Left Ventricular Function in Patients With Heart Failure and Preserved Ejection Fraction
Structured PICO
Is left atrial conduit function impaired in HFpEF and associated with exercise intolerance?
P
Population
Patients with heart failure and preserved ejection fraction (HFpEF)
I
Intervention
Cardiac magnetic resonance myocardial feature tracking
O
Outcome
Left atrial conduit strain and its association with exercise intolerancesurrogate
Impaired left atrial conduit function measured by CMR is a distinct feature of HFpEF that contributes to exercise intolerance independently of LV stiffness.
Abstract
BACKGROUND: Although left atrial (LA) dysfunction is common in heart failure with preserved ejection fraction (HFpEF), its functional implications beyond the reflection of left ventricular (LV) pathology are not well understood. The aim of this study was to further characterize LA function in HFpEF patients. METHODS AND RESULTS: =0.06). CONCLUSIONS: Cardiac magnetic resonance myocardial feature tracking-derived conduit strain is significantly impaired in HFpEF and associated with exercise intolerance. Impaired conduit function is associated with impaired early ventricular filling, as potential mechanism leading to impaired oxygen uptake. Our results propose that impaired LA conduit function represents a distinct feature of HFpEF, independent of LV stiffness and relaxation. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02459626.