Parkinson's disease was an independent risk factor for elevated left ventricular filling pressures (OR 2.7; 95% CI 2.2-6.3; P=0.004) and was associated with increased left ventricular hypertrophy.
Cross-Sectional (n=100)
Blind
Is Parkinson's disease associated with structural and functional cardiac alterations compared to healthy controls?
Parkinson's disease is significantly associated with concentric left ventricular hypertrophy, diastolic dysfunction, and prolonged QT intervals, suggesting cardiomyopathy may be a non-motor symptom of the disease.
Effect estimate: OR 2.7 (95% CI 2.2-6.3)
p-value: p=0.004
Parkinson's disease (PD) patients have most frequently heart failure. The cause of this increased prevalence is not known. We designed a study to assess the cardiac function and cardiac structure in patients with PD compared to a control group. METHODS: Cross-sectional study with 50 PD patients and 50 healthy matched controls. We performed electro and echocardiograms to all patients and controls. The measurements were blind. In addition, we performed a neurological assessment. RESULTS: ; P = 0.01). PD was an independent risk factor for elevated left ventricular filling pressures (OR = 2.7, CI 95% 2.2-6.3; P = 0.004). Concentric remodeling and left ventricular hypertrophy were associated with more advanced Hoehn and Yahr stages. Moreover, patients with more dysautonomia symptoms showed more left ventricular hypertrophy. Finally, PD group had longer QT interval than control group regardless of the drugs. CONCLUSIONS: PD is significantly associated with increased concentric left ventricular hypertrophy and diastolic dysfunction. Advanced stages of PD are associated with a more severe cardiac affection. These findings can explain the increase of heart failure in PD patients. Cardiomyopathy could be a non-motor parkinsonian symptom.
Piqueras‐Flores et al. (Mon,) conducted a cross-sectional in Parkinson's disease (n=100). Parkinson's disease vs. Healthy matched controls was evaluated on Elevated left ventricular filling pressures (OR 2.7, 95% CI 2.2-6.3, p=0.004). Parkinson's disease was an independent risk factor for elevated left ventricular filling pressures (OR 2.7; 95% CI 2.2-6.3; P=0.004) and was associated with increased left ventricular hypertrophy.
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