January 1, 2017Open Access
Understanding neurologic complications following TAVI
Structured PICO
P
Population
Patients with severe, symptomatic aortic stenosis undergoing transcatheter aortic valve replacement (TAVI)
I
Intervention
Transcatheter aortic valve replacement (TAVI) and neuroprotective devices
O
Outcome
Peri-procedural stroke rates and neurologic complicationssafety
This review highlights the importance of standardized stroke definitions and careful endpoint selection when evaluating neuroprotective devices to mitigate peri-procedural stroke risk during TAVI.
Abstract
Transcatheter aortic valve replacement is a groundbreaking treatment modality for severe, symptomatic aortic stenosis. Despite the rapid progression in indications to include intermediate-risk patients, the risk of peri-procedural stroke remains, with a higher incidence rate than previously reported. Accurate assessment of peri-procedural stroke rates requires selection of careful and meaningful trial endpoints during evaluation of neuroprotective devices. In this article, we review recommendations and stroke definitions from academic research consortiums along with device trial results.