Preintervention microvascular sensitivity (g ATP) measured by ASL was significantly lower in patients with limited improvement post-revascularization versus resolved symptoms (4.93 vs 8.72, P=0.0466).
Cohort (n=19)
Do novel perfusion indices derived from arterial spin labeling reactive hyperemia correlate with symptom severity and response to revascularization in patients with peripheral arterial disease?
ASL reactive hyperemia measures of microvascular dysfunction may predict prognosis and symptom resolution following revascularization in patients with peripheral arterial disease.
Absolute Event Rate: 8.72% vs 4.93%
p-value: p=0.0466
Background Previously, a theoretical model based on microvascular physiology was established to facilitate the interpretation of calf perfusion dynamics recorded by arterial spin labeling (ASL). Purpose To investigate the clinical relevance of novel perfusion indices by comparing them to the symptoms, response to revascularization, and short‐term functional outcome in patients with peripheral arterial disease (PAD). Study Type Prospective cohort study. Population Nineteen patients with PAD. Field Strength/Sequence Pulsed ASL at 3T. Assessment The mid‐calf reactive hyperemia induced by 2 minutes of arterial occlusion was recorded in PAD patients. The perfusion responses were characterized by the peak, time‐to‐peak, and physiological model‐derived indices including the baseline perfusion f r , arterial resistance R a , and compliance C a , and sensitivity g ATP and response time τ ATP of downstream microvasculature to metabolic stress. These indices were compared to the disease severity and outcome within 6 months after revascularization assessed by self‐reported symptoms and the ankle‐brachial index. Disease severity was categorized as asymptomatic, claudication, or critical limb ischemia. The outcome was categorized as symptom resolved or limited improvement. Statistical Tests Severity and outcome groups were compared using Mann–Whitney and Kruskal–Wallis tests with Holm–Sidak adjustments. Results The peak perfusion decreased and model arterial resistance increased progressively with increasing severity of limb ischemia ( P = 0.0402 and 0.0413, respectively). Eleven patients had a successful endovascular procedure, including six patients who had symptoms resolved, four patients who had remaining leg pain, and one patient lost to follow‐up. The subjects with limited improvement had significantly lower preintervention microvascular sensitivity g ATP than those with symptoms resolved (8.72 ± 1.46 vs. 4.93 ± 0.91, P = 0.0466). Data Conclusion ASL reactive hyperemia reflects multiple aspects of the pathophysiology. Measures of macrovascular arterial disease are related to the manifested symptom severity, whereas preintervention g ATP associated with microvascular dysfunction is related to prognosis following revascularization. Level of Evidence: 1 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2018;47:1578–1588.
Chen et al. (Tue,) conducted a cohort in Peripheral arterial disease (PAD) (n=19). Arterial spin labeling (ASL) reactive hyperemia was evaluated on Preintervention microvascular sensitivity (g ATP) in patients with symptoms resolved vs limited improvement (p=0.0466). Preintervention microvascular sensitivity (g ATP) measured by ASL was significantly lower in patients with limited improvement post-revascularization versus resolved symptoms (4.93 vs 8.72, P=0.0466).
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