What explains the discordance between Fractional Flow Reserve (FFR) and Instantaneous Wave-Free Ratio (iFR) in angiographically intermediate coronary stenoses?
Discordance between FFR and iFR in intermediate stenoses is driven by differences in hyperemic coronary flow velocity, suggesting FFR+/iFR- lesions may behave physiologically like unobstructed vessels.
FFR/iFR disagreement was explained by differences in hyperemic coronary flow velocity. Furthermore, coronary stenoses classified as FFR+/iFR- demonstrated similar coronary flow characteristics to angiographically unobstructed vessels.
Cook et al. (Fri,) studied this question.
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