Well-trained middle-aged men exhibited lower basal platelet reactivity and more potent platelet inhibition by dual antiplatelet therapy compared to untrained men.
Cross-Sectional (n=42)
Does habitual physical activity level affect platelet reactivity and the efficacy of dual antiplatelet therapy in healthy middle-aged men?
A habitually active lifestyle increases platelet sensitivity to pharmacological and physiological inhibitors, suggesting physical activity status should be considered when optimizing antithrombotic therapy.
antagonist) alongside lifestyle modifications, including more regular physical activity. It is currently unknown whether regular exercise affects the pharmacology of DAPT. AIM: To explore how exercise-induced improvements in vascular and platelet function affect the efficacy of DAPT, in a cross-sectional study of men with different physical activity levels (training status). METHODS: A total of 42 healthy, normal-weight, middle-aged men were divided into 3 groups: untrained, moderately trained and well-trained. Their platelet reactivity (agonist-induced % aggregation) was investigated in platelet-rich plasma at rest and after inhibition with aspirin and ticagrelor and/or prostacyclin and nitric oxide added to the blood in vitro, and after physiological tests of vascular function; passive movement of the leg, flow-mediated dilation and one-leg knee-extensor exercise. Vascular function of the femoral artery (changes in arterial blood flow) was assessed by ultrasound Doppler. RESULTS: Platelets from the well-trained subjects had lower basal reactivity, a higher sensitivity to the anti-aggregatory effects of prostacyclin and were more potently inhibited by DAPT compared to the untrained subjects. The moderately trained and well-trained subjects had a superior vascular function compared to untrained subjects, and their platelets were more inhibited by the passive movement, flow-mediated dilation and one-leg knee-extensor exercise. DISCUSSION: A habitually active lifestyle leads to an increased platelet sensitivity to pharmacological and physiological platelet inhibitors. We suggest that physical activity habits (training status) should be considered when personalizing and optimizing antithrombotic treatment strategies.
Slingsby et al. (Wed,) conducted a cross-sectional in Healthy (n=42). Habitual physical activity (well-trained or moderately trained) vs. Untrained was evaluated on Platelet reactivity and vascular function. Well-trained middle-aged men exhibited lower basal platelet reactivity and more potent platelet inhibition by dual antiplatelet therapy compared to untrained men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: