What is the clinical evidence from this study?

Study design: Cohort. Population: Sudden sensory neural hearing loss (n=22335). Intervention: Sudden sensory neural hearing loss vs. Subjects with no history of sudden sensory neural hearing loss. Primary outcome: Myocardial infarction (HR 1.10, 95% CI 0.81-1.50, p=0.535).

January 11, 2018Scientific Reports21 citationsOpen Access

Sudden sensory neural hearing loss is not predictive of myocardial infarction: A longitudinal follow-up study using a national sample cohort

SKSo Young Kim SSSongyong Sim HKHyung‐Jong Kim

Key Result

Sudden sensory neural hearing loss was not associated with an increased risk of myocardial infarction (adjusted HR 1.10) when compared to a control group matched for demographic factors and medical history.

Study Design

Type

Cohort (n=22,335)

Structured PICO

Does sudden sensory neural hearing loss increase the risk of myocardial infarction?

Population

22,335 participants (4,467 with sudden sensory neural hearing loss and 17,868 matched controls) from a Korean national cohort, followed for up to 12 years to evaluate the risk of myocardial infarction.

Exposure

Sudden sensory neural hearing loss (SSNHL)

Comparator

Control group without SSNHL, matched by demographics and medical history (Study I) or demographics only (Study II)

Outcome

Myocardial infarction (MI)hard clinical

Sudden sensory neural hearing loss is not an independent risk factor for myocardial infarction when adequately adjusting for baseline cardiovascular comorbidities.

Main Result

Hazard Ratio: 1.1 (95% CI 0.81–1.5)

Absolute Event Rate: 213.2% vs 193.3%

p-value: p=0.535

Limitations

Possible confounders not considered, including cerebrovascular diseases and thrombotic risk factors
Audiometric patterns of SSNHL could not be delineated in data of a large population cohort
Degree or severity of MI could not be assessed

Abstract

The aim of this study was to evaluate the risk of myocardial infarction (MI) in SSNHL subjects with differently matched control groups. The Korean Health Insurance Review and Assessment Service - National Sample Cohort recruited subjects from 2002 to 2013. We used two study designs. In study I, we matched 4,467 SSNHL participants with a control group (17,868 subjects with no history of SSNHL) based on demographic factors (age, sex, income, and region of residence) and medical history (diabetes, dyslipidemia, and hypertension). In study II, we matched 4,467 SSNHL participants with a control group based on only demographic factors. The crude (simple) and adjusted hazard ratios (HRs) of SSNHL with MI were analyzed using the Cox-proportional hazard model. In study I, SSNHL was not associated with increased risk of MI. However, in study II, SSNHL was associated with increased risk of MI (adjusted HR = 1.39 95% CI = 1.00-1.93, P = 0.048). The SSNHL group did not exhibit increased risk of MI when compared to the control group matched by both demographic factors and medical history. However, compared to the control group not matched by medical history, the relative risk of MI was increased in the SSNHL group.

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