The coexistence of vascular calcification and left ventricular hypertrophy in hemodialysis patients significantly increased the risk of death or cardiovascular events compared to neither condition (HR 1.88).
Cohort (n=341)
No
Does the coexistence of vascular calcification and left ventricular hypertrophy increase the risk of deaths and cardiovascular events in hemodialysis patients?
In hemodialysis patients, the coexistence of vascular calcification and left ventricular hypertrophy synergistically increases the risk of mortality and cardiovascular events.
Effect estimate: HR 1.88 (95% CI 1.15-3.06)
Absolute Event Rate: 57.1% vs 32.5%
p-value: p=0.011
We examined the relationship and combined effect of vascular calcification (VC) and left ventricular hypertrophy (LVH) on deaths and cardiovascular events (CVEs) in hemodialysis (HD) patients. Methods: Maintenance HD patients (n=341) were included. Echocardiography data and plain chest radiographs were used to assess LVH and aortic arch VC. Results: VC was found in 100 patients (29.3%). LVH was more prevalent in patients with VC compared with those without VC (70% vs. 50.2%, P=0.001). VC was independently associated with a 2.42-fold increased risk of LVH (95% CI, 1.26-4.65). In multivariate analysis, compared with patients with neither VC nor LVH, the coexistence of VC and LVH was independently associated with CVE (HR, 2.01; 95% CI, 1.09-3.72), whereas VC or LVH alone was not. Patients with both VC and LVH had the highest risk for a composite event of deaths or CVE (HR, 1.88; 95% CI, 1.15-3.06). Significant synergistic interaction was observed between VC and LVH (P for interaction=0.039). Conclusions: VC was independently associated with LVH. The coexistence of VC and LVH was associated with higher risk of deaths and CVEs than either factor alone. VC and LVH showed a synergistic interaction for the risk of deaths and CVEs.
Hwang et al. (Mon,) conducted a cohort in End-stage renal disease on maintenance hemodialysis (n=341). Coexistence of vascular calcification and left ventricular hypertrophy vs. Neither vascular calcification nor left ventricular hypertrophy was evaluated on Composite of patient death or cardiovascular event (HR 1.88, 95% CI 1.15-3.06, p=0.011). The coexistence of vascular calcification and left ventricular hypertrophy in hemodialysis patients significantly increased the risk of death or cardiovascular events compared to neither condition (HR 1.88).