Does exposure to QT prolonging drugs increase the risk of QT prolongation, TdP, and ventricular arrhythmias?
Patients exposed to QT prolonging drugs
QT prolonging drugs (single or multiple concomitant use)
Incidence of QT prolongation, Torsades de Pointes (TdP), and ventricular arrhythmiassafety
While QT prolongation occurs in approximately 6% of patients exposed to QT-prolonging drugs, the progression to severe clinical arrhythmias like TdP is rare (0.3%), though the risk is compounded by polypharmacy.
Around 6% of patients have risk of QT prolongation when exposed but only 0.3% developed TdP and 2.6% developed ventricular arrhythmias. Risk of developing arrhythmias is higher with concomitant use of multiple QT prolonging drugs.
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Karuppiah Arunachalam
Seetha Lakshmanan
Abhishek Maan
Journal of Clinical Medicine Research
Brown University
Louisiana State University Health Sciences Center Shreveport
AIMST University
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Arunachalam et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69d73b99c74376700bf30dd1 — DOI: https://doi.org/10.14740/jocmr3338w