CCR2+ monocyte-derived infiltrating macrophages are required for adverse cardiac remodeling during pressure overload and represent a potential therapeutic target for heart failure.
CCR2+ monocyte-derived infiltrating macrophages are required for adverse cardiac remodeling during pressure overload, highlighting a potential immunomodulatory therapeutic target for heart failure.
monocytes/macrophages may be an important immunomodulatory therapeutic target to ameliorate pressure-overload HF.
Patel et al. (2018) studied this question. CCR2+ monocyte-derived infiltrating macrophages are required for adverse cardiac remodeling during pressure overload and represent a potential therapeutic target for heart failure.