The LA wall-mapping application demonstrated high accuracy and reproducibility for visualizing and quantifying global LA wall thickness, showing good correlation with pig heart specimens (r = 0.96, p < 0.001).
Observational (n=8)
Does a novel LA wall-mapping application accurately and reproducibly measure and visualize global LA wall thickness compared to physical/digital phantoms and pig heart specimens?
A novel LA wall-mapping application provides accurate and highly reproducible visualization and quantification of global LA wall thickness from cardiac CT images.
Effect estimate: r = 0.96
p-value: p=<0.001
The measurement method for the LA wall thickness (WT) using cardiac computed tomography (CT) is observer dependent and cannot provide a rapid and comprehensive visualisation of the global LA WT. We aim to develop a LA wall-mapping application to display the global LA WT on a coplanar plane. The accuracy, intra-observer, and inter-observer reproducibility of the application were validated using digital/physical phantoms, and CT images of eight patients. This application on CT-based LA WT measures were further validated by testing six pig cardiac specimens. To evaluate its accuracy, the expanded maps of the physical phantom and pig LA were generated from the CT images and compared with the expanded map of the digital phantom and LA wall of pig heart. No significant differences (p > 0.05) were found between physical phantom and digital phantom as well as pig heart specimen and CT images using our application. Moreover, the analysis was based on the LA physical phantom or images of clinical patients; the results consistently demonstrated high intra-observer reproducibility (ICC > 0.9) and inter-observer reproducibility (ICC > 0.8) and showed good correlation between measures of pig heart specimen and CT data (r = 0.96, p < 0.001). The application can process and analyse the LA architecture for further visualisation and quantification.
Sun et al. (Fri,) conducted a observational in Atrial Fibrillation (n=8). Left Atrium wall-mapping application vs. Gold standard (digital phantom / pig heart specimen) was evaluated on Correlation of LA wall thickness between pig heart specimen and CT data (r = 0.96, p=<0.001). The LA wall-mapping application demonstrated high accuracy and reproducibility for visualizing and quantifying global LA wall thickness, showing good correlation with pig heart specimens (r = 0.96, p < 0.001).