Intramyocardial injection of exosomes from cardiosphere-derived cells significantly reduced scar size to 13% compared to 18% with placebo and preserved myocardial fiber architecture in a porcine model.
RCT (n=12)
Blinded to treatment groups for image analysis
Randomized
No
Does intramyocardial delivery of CDCEXO preserve myocardial fiber architecture and cardiac function in a porcine model of chronic myocardial infarction?
Intramyocardial delivery of CDCEXO preserves myocardial tissue architecture and function after myocardial infarction in a preclinical porcine model, as revealed by diffusion tensor cardiac MRI.
Absolute Event Rate: 13% vs 18%
p-value: p=0.03
The object of the study was to reveal the fiber microstructural response with diffusion tensor cardiac magnetic resonance after intramyocardial exosomes secreted by cardiosphere-derived cells (CDCEXO) in chronic porcine myocardial infarction. Porcine with myocardial infarction underwent intramyocardial delivery of human CDCEXO and placebo in a randomized placebo-controlled study. Four weeks after injection, viability improved in the CDCEXO group, whereas myocardial fiber architecture and cardiac function were preserved. In the placebo group, fiber architecture and cardiac function declined. Myocardial regeneration by CDCEXO is not tumor-like; instead, details of tissue architecture are faithfully preserved, which may foster physiological excitation and contraction.
Nguyen et al. (Thu,) conducted a rct in Myocardial Infarction (n=12). Exosomes from cardiosphere-derived cells (CDC EXO) vs. Placebo (vehicle only) was evaluated on Scar size (SS) at 4 weeks post-injection (p=0.03). Intramyocardial injection of exosomes from cardiosphere-derived cells significantly reduced scar size to 13% compared to 18% with placebo and preserved myocardial fiber architecture in a porcine model.