A lower platelet count-spleen diameter ratio was significantly associated with large oesophageal varices, with median platelet counts of 90,100 in large vs 200,000 in small varices.
Cross-Sectional (n=100)
No
Does the platelet count-spleen diameter ratio predict the presence and grade of oesophageal varices in patients with hepatic cirrhosis?
Low platelet count, higher spleen size, and lower platelet count-spleen diameter ratio are significantly associated with the presence of large oesophageal varices in patients with hepatic cirrhosis.
BACKGROUND cirrhotic patients will develop oesophageal varices over their lifetime and the annual rate of oesophageal haemorrhage is 5 to 15%. Current guidelines recommend using Upper Gastrointestinal Endoscopy (UGIE) to screen all cirrhotic patients at for identification of varices at a high risk of bleeding. In a limited resources setting like ours where financial constraints a major problem predicting the presence and grade of varices by non-invasive methods serves to help a lot in various ways. aim of the study is to find out the relevance of platelet count-spleen diameter ratio as a non-invasive predictor of varices in patients with hepatic cirrhosis. AND METHODS present study was conducted on 100 patients admitted with a diagnosis of cirrhosis of liver in general medicine wards of. K. C. G. Medical College, Brahmapur, during the period of 2 years. All the patients underwent detailed clinical evaluation, total count, ultrasound abdomen and varices were graded by upper GI endoscopy with Paquet’s grading. Analysis- All data were entered in Excel 2007 and statistical analysis was performed using the statistical software 16. 0. Data were expressed as frequency (in percentages), median values (with range (minimum, maximum) ). For variables, Mann-Whitney U test was performed to find the differences between two groups. Design- Cross-sectional analytic study. 100 patients with hepatic cirrhosis were evaluated with upper GI endoscopy, ultrasound abdomen and total platelet count. platelet count in large varices group was 90, 100 and in small varices group was 2 lakhs. Large varices were significantly with increasing spleen size, median value - 182. 5 mm. Platelet count-spleen diameter ratio was significantly low in with higher grade of oesophageal varices. study shows significant association between low platelet count, higher spleen size and lower platelet count-spleen diameter with the presence of large oesophageal varices. These parameters can be used as non-invasive predictors of oesophageal in patients with hepatic cirrhosis, but never comparable with upper GI endoscopy in terms of sensitivity and specificity prediction of variceal haemorrhage.
Minz et al. (Fri,) conducted a cross-sectional in Hepatic cirrhosis (n=100). Platelet count-spleen diameter ratio vs. Upper Gastrointestinal Endoscopy was evaluated on Presence and grade of oesophageal varices. A lower platelet count-spleen diameter ratio was significantly associated with large oesophageal varices, with median platelet counts of 90,100 in large vs 200,000 in small varices.
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