The ALDH2 Glu504Lys variant significantly increased the risk of major adverse cardiac events compared to wild-type in ACS patients (21.0% vs 9.2%; HR 2.443, 95% CI 1.390-4.296, P=0.002).
Cohort (n=377)
Does the ALDH2 Glu504Lys variant predict a worse prognosis in acute coronary syndrome patients?
The ALDH2 Glu504Lys variant is associated with a significantly increased risk of MACE and cardiac death in patients with acute coronary syndrome.
Hazard Ratio: 2.443 (95% CI 1.39–4.296)
Absolute Event Rate: 21% vs 9.2%
p-value: p=.002
Aldehyde dehydrogenase 2 (ALDH2) Glu504Lys variant was an independent risk factor for acute coronary syndrome (ACS). However, there are lacking researches about the relationship between the variant and prognosis of ACS. In the prospective study, 377 ACS patients were grouped into the wild-type (*1/*1) and the mutation (*2/*2 + *1/*2) groups according to genotype detection. Compared with the wild-type group, incidences of major adverse cardiac events (MACE) and cardiac death were both higher in the mutation group (9.2% vs 21.0%, P = .002; 5.2% vs 12.2%, P = .026); the MACE-free and the cardiac-death-free cumulative survival rates were obviously lower in the mutation group. Moreover, the mutant genotypes were associated with significantly increased risk of MACE and cardiac death (HR 2.443, 95%CI: 1.390-4.296, P = .002; HR 2.727, 95%CI: 1.303-5.708, P = .008). These results suggested that ALDH2 Glu504Lys variant could predict a worse prognosis of ACS patients.
Pan et al. (Wed,) conducted a cohort in Acute coronary syndrome (n=377). ALDH2 Glu504Lys variant vs. Wild-type (*1/*1) genotype was evaluated on Major adverse cardiac events (MACE) (HR 2.443, 95% CI 1.390-4.296, p=.002). The ALDH2 Glu504Lys variant significantly increased the risk of major adverse cardiac events compared to wild-type in ACS patients (21.0% vs 9.2%; HR 2.443, 95% CI 1.390-4.296, P=0.002).
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