Exercise training is proposed as a strategy to improve cardiovascular reserve capacity and manage cancer treatment-induced cardiovascular toxicity, supported by a conceptual research framework.
Does exercise therapy improve cardiovascular toxicity in adult patients with cancer?
Exercise training is highlighted as a potential therapeutic strategy to mitigate cancer treatment-induced cardiovascular toxicity, with a proposed framework for future research.
Cardio-oncology is an emerging discipline focused predominantly on the detection and management of cancer treatment-induced cardiac dysfunction (cardiotoxicity), which predisposes to development of overt heart failure or coronary artery disease. The direct adverse consequences, as well as those secondary to anticancer therapeutics, extend beyond the heart, however, to affect the entire cardiovascular-skeletal muscle axis (ie, whole-organism cardiovascular toxicity). The global nature of impairment creates a strong rationale for treatment strategies that augment or preserve global cardiovascular reserve capacity. In noncancer clinical populations, exercise training is an established therapy to improve cardiovascular reserve capacity, leading to concomitant reductions in cardiovascular morbidity and its attendant symptoms. Here, we overview the tolerability and efficacy of exercise on cardiovascular toxicity in adult patients with cancer. We also propose a conceptual research framework to facilitate personalized risk assessment and the development of targeted exercise prescriptions to optimally prevent or manage cardiovascular toxicity after a cancer diagnosis.
Scott et al. (Mon,) conducted a review in Cancer treatment-induced cardiovascular toxicity. Exercise therapy was evaluated. Exercise training is proposed as a strategy to improve cardiovascular reserve capacity and manage cancer treatment-induced cardiovascular toxicity, supported by a conceptual research framework.