Prolongation of the QTc interval > 440 ms independently predicted all-cause mortality (HR 1.40) at 24 months in patients with suspected acute myocardial infarction.
Cohort (n=4,042)
Yes
Effect estimate: HR 1.40 (95% CI 1.07-1.83)
Absolute Event Rate: 11.4% vs 4.3%
p-value: p=0.01
BACKGROUND: While prolongation of QRS duration and QTc interval during acute myocardial infarction (AMI) has been reported in animals, limited data is available for these readily available electrocardiography (ECG) markers in humans. METHODS: Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected AMI in a prospective diagnostic multicentre study were prospectively assessed. Digital 12-lead ECGs were recorded at presentation. QRS duration and QTc interval were automatically calculated in a blinded fashion. Final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 24 months of follow-up. RESULTS: Among 4042 patients, AMI was the final diagnosis in 19% of patients. Median QRS duration and median QTc interval were significantly greater in patients with AMI compared to those with other final diagnoses (98 ms IQR 88-108 vs. 94 ms IQR 86-102 and 436 ms IQR 414-462 vs. 425 ms IQR 407-445, p 120 ms compared to a QRS duration ≤ 120 ms (p 440 ms compared to a QRS duration ≤ 440 ms (p 120 ms and QTc interval > 440 ms predict mortality in patients with suspected AMI, but do not add diagnostic value.
Cupa et al. (Tue,) conducted a cohort in Suspected acute myocardial infarction (n=4,042). QTc interval > 440 ms vs. QTc interval ≤ 440 ms was evaluated on All-cause mortality (HR 1.40, 95% CI 1.07-1.83, p=0.01). Prolongation of the QTc interval > 440 ms independently predicted all-cause mortality (HR 1.40) at 24 months in patients with suspected acute myocardial infarction.