Having an infant with a critical congenital heart defect increased the risk of maternal cardiovascular hospitalization compared to having an infant with no defects (HR 1.43; 95% CI 1.13-1.82).
Cohort (n=1,084,251)
Does having an infant with a congenital heart defect increase the risk of future cardiovascular hospitalization in women?
Women who deliver infants with congenital heart defects have a significantly higher long-term risk of cardiovascular hospitalization, suggesting infant congenital heart defects may be an early marker of maternal cardiovascular disease predisposition.
Hazard Ratio: 1.43 (95% CI 1.13–1.82)
Absolute Event Rate: 3.38% vs 2.42%
BACKGROUND: The possibility that congenital heart defects signal a familial predisposition to cardiovascular disease has not been investigated. We aimed to determine whether the risk of cardiovascular disorders later in life was higher for women who have had newborns with congenital heart defects. METHODS: We studied a cohort of 1 084 251 women who had delivered infants between 1989 and 2013 in Quebec, Canada. We identified women whose infants had critical, noncritical, or no heart defects, and tracked the women over time for future hospitalizations for cardiovascular disease, with follow-up extending up to 25 years past pregnancy. We calculated the incidence of cardiovascular hospitalization per 1000 person-years, and used Cox proportional hazards regression to estimate hazard ratios and 95% confidence intervals (CIs) for the association between infant heart defects and risk of maternal cardiovascular hospitalization. Models were adjusted for age, parity, preeclampsia, comorbidity, material deprivation, and time period. RESULTS: Women whose infants had heart defects had a higher overall incidence of cardiovascular hospitalization. There were 3.38 cardiovascular hospitalizations per 1000 person-years for those with critical defects (95% CI, 2.67-4.27), 3.19 for noncritical defects (95% CI, 2.96-3.45), and 2.42 for no heart defects (95% CI, 2.39-2.44). In comparison with no heart defects, women whose infants had critical defects had a hazard ratio of 1.43 (95% CI, 1.13-1.82) for any cardiovascular hospitalization, and women whose infants had noncritical defects had a hazard ratio of 1.24 (95% CI, 1.15-1.34), in adjusted models. Risks of specific causes of cardiovascular hospitalization, including myocardial infarction, heart failure, and other atherosclerotic disorders, were also greater for mothers of infants with congenital heart defects than with no defects. CONCLUSIONS: Women whose infants have congenital heart defects have a greater risk of cardiovascular hospitalization later in life. Congenital heart defects in offspring may be an early marker of predisposition to cardiovascular disease.
Auger et al. (Mon,) conducted a cohort in Cardiovascular disease (n=1,084,251). Infant with critical congenital heart defect vs. Infant with no heart defects was evaluated on Cardiovascular hospitalization (HR 1.43, 95% CI 1.13-1.82). Having an infant with a critical congenital heart defect increased the risk of maternal cardiovascular hospitalization compared to having an infant with no defects (HR 1.43; 95% CI 1.13-1.82).