April 1, 2018Open Access
View Full PaperPulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease
Structured PICO
Do pulmonary effective arterial elastance and pulmonary arterial compliance better predict mortality than pulmonary vascular resistance or transpulmonary gradient in patients with pulmonary hypertension due to left heart disease?
P
Population
Patients with left heart disease with pulmonary hypertension, including heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, and pulmonary hypertension with a normal pulmonary vascular resistance
I
Intervention
Assessment of pulmonary effective arterial elastance (Ea) and pulmonary arterial compliance
C
Comparator
Assessment of pulmonary vascular resistance or transpulmonary gradient
O
Outcome
Mortalityhard clinical
Pulmonary effective arterial elastance and pulmonary arterial compliance are superior prognostic markers for mortality compared to traditional measures like pulmonary vascular resistance in patients with pulmonary hypertension due to left heart disease.
Abstract
Pulmonary Ea and pulmonary arterial compliance more consistently predicted mortality than pulmonary vascular resistance or transpulmonary gradient across a spectrum of left heart disease with pulmonary hypertension, including patients with heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, and pulmonary hypertension with a normal pulmonary vascular resistance.