Being in the highest tertile of caffeine intake (>320 mg/day) was associated with a significantly lower 12-year incidence of atrial fibrillation (HR 0.249; 95% CI 0.161-0.458; P<0.01).
Cohort (n=1,475)
Does higher chronic caffeine intake reduce incident atrial fibrillation in the general population?
Higher chronic caffeine intake (>320 mg/day) is associated with a significantly reduced risk of incident atrial fibrillation in the general population, challenging the common belief that caffeine triggers this arrhythmia.
Hazard Ratio: 0.249 (95% CI 0.161–0.458)
Absolute Event Rate: 2.2% vs 10.2%
p-value: p=< 0.01
Background The general belief is that caffeine increases the risk of hyperkinetic arrhythmias, including atrial fibrillation. The aim of this study is to investigate the effect of chronic caffeine intake on incident atrial fibrillation in general population. Design and methods A population cohort of 1475 unselected men and women observed for 12 years and left free to intake food or beverages containing caffeine was studied. Subjects were stratified into tertiles of caffeine intake both in the whole cohort and after genotyping for the -163C > A polymorphism of the CYP1A2 gene, regulating caffeine metabolism. Results In the whole cohort, the 12-year incidence of atrial fibrillation was significantly lower in the third (2.2%) than in the first (10.2%) or second (5.7%) tertile of caffeine intake ( P 165 mmol/day or > 320 mg/day) is associated with a lower incidence of atrial fibrillation in the 12-year epidemiological prospective setting based on the general population.
Casiglia et al. (Wed,) conducted a cohort in atrial fibrillation (n=1,475). Higher caffeine intake (third tertile, >320 mg/day) vs. Lower caffeine intake (first or second tertile) was evaluated on incident atrial fibrillation (HR 0.249, 95% CI 0.161-0.458, p=< 0.01). Being in the highest tertile of caffeine intake (>320 mg/day) was associated with a significantly lower 12-year incidence of atrial fibrillation (HR 0.249; 95% CI 0.161-0.458; P<0.01).