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Background and objectives Kidney injury is a significant complication for patients undergoing hematopoietic cell transplantation (HCT), but few studies have prospectively examined changes in GFR in long-term survivors of HCT. We described the association between changes in GFR and all-cause mortality in patients up to 10 years after HCT. Design, setting, participants, range, 18–76 years; 64% were men; 87% were white) were followed for a median 5.3 years after HCT. The largest decreases in eGFR occurred within the first year post-transplant, with the eGFR decreasing from a median of 98 ml/min per 1.73 m 2 at baseline to 78 ml/min per 1.73 m 2 by 1 year post-HCT. Two thirds of patients had an eGFR<90 ml/min per 1.73 m 2 at 1 year after transplant. When modeled as a continuous variable, as eGFR declined from approximately 60 ml/min per 1.73 m 2 , the hazard of mortality progressively increased relative to a normal eGFR of 90 ml/min per 1.73 m 2 ( P <0.001). For example, when compared with an eGFR of 90 ml/min per 1.73 m 2 , the hazard ratios for eGFR of 60, 50, and 40 ml/min per 1.73 m 2 are 1.15 (95% confidence interval, 0.87 to 1.53), 1.68 (95% confidence interval, 1.26 to 2.24), and 2.67 (95% confidence interval, 1.99 to 3.60), respectively. Diabetes, hypertension, acute graft versus host disease, and cytomegalovirus infection were independently associated with a decline in GFR, whereas calcineurin inhibitor levels, chronic graft versus host disease, and albuminuria were not. Conclusions Adult HCT recipients have a high risk of decreased eGFR by 1 year after HCT. Although eGFR remains fairly stable thereafter, a decreased eGFR is significantly associated with higher risk of mortality, with a progressively increased risk as eGFR declines.
Hingorani et al. (Wed,) studied this question.