Moderate to severe obstructive sleep apnoea was not independently associated with arterial stiffness in people with Type 2 diabetes (carotid-femoral pulse wave velocity 10.7 vs 10.3 m/s; P=0.513).
Case-Control (n=71)
Does moderate to severe obstructive sleep apnoea increase arterial stiffness in people with Type 2 diabetes?
Moderate to severe obstructive sleep apnoea is not independently associated with increased arterial stiffness in non-sleepy people with Type 2 diabetes after adjusting for age and blood pressure.
Absolute Event Rate: 10.7% vs 10.3%
p-value: p=0.513
Abstract Aims To examine whether people with Type 2 diabetes with concurrent obstructive sleep apnoea have increased arterial stiffness as compared with people with Type 2 diabetes without obstructive sleep apnoea. Methods In a study with a case–control design, 40 people with Type 2 diabetes and treatment‐naïve moderate to severe obstructive sleep apnoea (Apnoea‐Hypopnoea Index ≥15) and a control group of 31 people with Type 2 diabetes without obstructive sleep apnoea (Apnoea‐Hypopnoea Index <5) were examined. Obstructive sleep apnoea status was evaluated using the ApneaLink ® + home‐monitoring device (Resmed Inc., San Diego, CA , USA ), providing the Apnoea‐Hypopnoea Index scores. Arterial stiffness was assessed according to carotid‐femoral pulse wave velocity using the Sphygmocor device and the oscillometric Mobil‐O‐Graph ® (I.E.M. GmbH, Stolberg, Germany). Results Carotid‐femoral pulse wave velocity was not significantly different between participants with Type 2 diabetes with obstructive sleep apnoea and those without obstructive sleep apnoea (10.7±2.2 m/s vs 10.3±2.1 m/s; P =0.513), whereas oscillometric pulse wave velocity was significantly higher in participants with Type 2 diabetes with obstructive sleep apnoea than in those without obstructive sleep apnoea (9.5±1.0 m/s vs 8.6±1.4 m/s; P =0.002). In multiple regression analysis, age ( P =0.002), gender (men; P =0.018) and HbA 1c ( P =0.027) were associated with carotid‐femoral pulse wave velocity, and systolic blood pressure ( P =0.004) and age ( P <0.001) were associated with oscillometric pulse wave velocity. After adjustment, presence of obstructive sleep apnoea was not independently associated with pulse wave velocity whether assessed by tonometry or oscillometry. Conclusion In conclusion, the present study did not find an age‐ and blood pressure‐independent association between moderate to severe obstructive sleep apnoea and arterial stiffness in non‐sleepy people with Type 2 diabetes. (Clinical trial registration number: NCT02482584)
Kristiansen et al. (Tue,) conducted a case-control in Type 2 diabetes and obstructive sleep apnoea (n=71). Moderate to severe obstructive sleep apnoea vs. No obstructive sleep apnoea was evaluated on Arterial stiffness assessed by carotid-femoral pulse wave velocity (p=0.513). Moderate to severe obstructive sleep apnoea was not independently associated with arterial stiffness in people with Type 2 diabetes (carotid-femoral pulse wave velocity 10.7 vs 10.3 m/s; P=0.513).