May 17, 2018Open Access
View Full PaperTwenty‐Year Trends in the American Heart Association Cardiovascular Health Score and Impact on Subclinical and Clinical Cardiovascular Disease: The Framingham Offspring Study
Key Result
Compared with maintaining high cardiovascular health, persistently low scores over 20 years increased the risk of CVD (HR 1.9), death (HR 1.4), and subclinical disease (OR 2.86).
Study Design
Type
Cohort
Structured PICO
Do different trajectories of American Heart Association Cardiovascular Health Scores impact the risk of subclinical disease, clinical CVD, and death?
P
Population
Participants in the Framingham Offspring Study
I
Intervention
American Heart Association Cardiovascular Health (CVH) Score trajectories (high-low, low-high, and low-low groups)
C
Comparator
High-high CVH score group
O
Outcome
Subclinical disease, clinical cardiovascular disease (CVD), and deathhard clinical
Decreasing ideal cardiovascular health scores over 20 years are associated with increased risks of subclinical disease, clinical CVD, and death, highlighting the importance of maintaining ideal cardiovascular health.
Main Result
Effect estimate: HR for CVD: 1.39, 1.73, 1.9; HR for death: 1.12, 1.57, 1.4; OR for subclinical disease: 1.61, 1.98, 2.86
p-value: p=<0.05
Abstract
BACKGROUND: Data on the temporal trends in ideal cardiovascular health (CVH) as well as on their association with subclinical/overt cardiovascular disease (CVD) and death are limited. METHODS AND RESULTS: <0.05 for all). The odds of subclinical disease and risk of CVD and death were higher for all compared with the high-high group (428 CVD and 367 death events, median follow-up 5.1 years, hazard ratios for CVD: 1.39, 1.73, 1.9 and death: 1.12, 1.57, 1.4 and odds ratios for subclinical disease: 1.61, 1.98, 2.86 for high-low, low-high, and low-low, respectively). CONCLUSIONS: The decreased presence of ideal CVH scores over the past 20 years resulted in increasing odds of subclinical disease and risk of CVD and death, emphasizing the importance of maintaining ideal CVH over the life course.