BMI was strongly associated with incident type 2 diabetes in younger adults, but the association decreased with age and was no longer evident in those aged 60-74 years (P interaction < 0.001).
Cohort (n=8,735)
What are the optimal BMI cut-off points for predicting incident type 2 diabetes in a Chinese population?
Age- and sex-specific BMI cut-off points should be utilized for T2DM risk stratification in the Chinese population, as the predictive performance of BMI decreases significantly with advancing age.
p-value: p=<0.001
Abstract Background The current body mass index (BMI) classifications have been established based on the risk of obesity‐related conditions, but not specifically on type 2 diabetes mellitus (T2DM). The aim of this study was to identify the optimal BMI cut‐off points for assessing incident T2DM risk in the Chinese population. Methods The longitudinal study cohort consisted of 8735 non‐diabetic participants aged 20–74 years at baseline, with a mean follow‐up period of 6.0 years. Body mass index, 2‐h plasma glucose after a 75‐g oral glucose tolerance test, and HbA1c were measured at baseline and follow‐up. Results During the follow‐up period, 825 participants were diagnosed with T2DM. In multivariable Cox regression analyses, after adjusting for covariates, a strong positive association between BMI and incident T2DM was found in the whole population; however, when stratified by age groups (20–39, 40–59, and 60–74 years), the risk associations between BMI and incident T2DM decreased with increasing age and were no longer evident in the 60–74 years group ( P interaction < 0.001). The optimal BMI cut‐off points for predicting T2DM risk for men and women were 25.5 and 24.4 kg/m 2 , respectively, in the 20–39 years group, and 23.5 and 23.0 kg/m 2 , respectively, in the 40–59 years group. There was no predictive performance of BMI in the 60–74 years group for either sex. Conclusions The results suggest that the performance of BMI in predicting T2DM risk was best in subjects of younger age and decreased with age. Age‐ and sex‐specific BMI cut‐off points should be considered for T2DM risk stratification in the Chinese population.
Ma et al. (Sat,) conducted a cohort in Type 2 diabetes mellitus (n=8,735). Body mass index was evaluated on Incident T2DM (p=<0.001). BMI was strongly associated with incident type 2 diabetes in younger adults, but the association decreased with age and was no longer evident in those aged 60-74 years (P interaction < 0.001).
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