Does inhibition of NLRP3 prevent atrial fibrillation?
Cardiomyocytes (CM)
Inhibition of NLRP3
Pathogenesis of atrial fibrillation (AF)
Inhibition of the NLRP3 inflammasome in cardiomyocytes represents a potential novel therapeutic approach for atrial fibrillation.
Our study establishes a novel pathophysiological role for CM NLRP3 inflammasome signaling, with a mechanistic link to the pathogenesis of AF, and establishes the inhibition of NLRP3 as a potential novel AF therapy approach.
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Chunxia Yao
Tina Veleva
Larry Scott
Circulation
Baylor College of Medicine
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Yao et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69d760ec086f9d6299f30bc4 — DOI: https://doi.org/10.1161/circulationaha.118.035202