A lower skeletal muscle mass to visceral fat area ratio was independently associated with increased arterial stiffness in patients with type 2 diabetes, with an OR of 4.33 in men and 4.66 in women for the lowest versus highest tertiles.
Cross-Sectional (n=423)
No
Does skeletal muscle mass to visceral fat area ratio (SVR) correlate with arterial stiffness in Chinese patients with type 2 diabetes mellitus?
A lower skeletal muscle mass to visceral fat area ratio (SVR) is independently associated with increased arterial stiffness in Chinese patients with type 2 diabetes, suggesting its utility as a risk-assessment tool for cardiovascular risk.
Odds Ratio: 4.33 (95% CI 1.06–17.78)
Absolute Event Rate: 56.1% vs 17.9%
p-value: p=0.04
The skeletal muscle mass-to-visceral fat area ratio (SVR) has been linked to arterial stiffness in non-diabetic adults. We examined the association between the SVR and arterial stiffness in patients with type 2 diabetes mellitus (T2DM). Patients with type 2 diabetes mellitus (252 men and 171 women) aged 40–75 years were enrolled and divided into three groups according to SVR tertiles. Arterial stiffness was measured as brachial-ankle pulse wave velocity (baPWV), with baPWV> 1800 mm/s defined as high. Spearman’s partial correlation was used to adjust confounding factors. The odds ratio for high baPWV was determined by multiple logistic regression analyses, and receiver-operating characteristic analysis was conducted. SVR was associated with baPWV in Chinese patients with T2DM (Spearman’s partial correlation = − 0.129, P < 0.01). SVR was found to be significantly associated with baPWV on multiple logistic regression analysis. Patients in the lower SVR tertiles had a higher OR than did those in the higher SVR tertiles, after adjusting for multiple covariates (Q1: OR = 4.33 in men and 4.66 in women; Q3: OR = 1). The area under the curve for SVR was significantly greater than that for appendicular skeletal muscle (ASM), ASM/height2, and visceral fat area (VAF) for identifying high baPWV (0.747 in men and 0.710 in women). The optimal cutoffs values of SVR for detecting high baPWV were 191.7 g/cm2 for men and 157.3 g/cm2 for women. SVR has an independent, negative association with arterial stiffness, and is a better risk-assessment tool than ASM, ASM/height2, and VFA in clinical practice to identify patients with type 2 diabetes at high cardiovascular risk.
Xu et al. (Tue,) conducted a cross-sectional in Type 2 diabetes mellitus (n=423). Lower skeletal muscle mass to visceral fat area ratio (SVR) vs. Higher SVR (highest tertile) was evaluated on High brachial-ankle pulse wave velocity (baPWV > 1800 mm/s) (OR 4.33, 95% CI 1.06-17.78, p=0.04). A lower skeletal muscle mass to visceral fat area ratio was independently associated with increased arterial stiffness in patients with type 2 diabetes, with an OR of 4.33 in men and 4.66 in women for the lowest versus highest tertiles.