Does achieved diastolic blood pressure outside the 70 to <80 mmHg range increase the risk of cardiovascular outcomes in high-risk patients achieving a target systolic blood pressure of 120 to <140 mmHg?
In high-risk patients with optimally controlled systolic blood pressure, both low and high diastolic blood pressures are associated with increased cardiovascular risk, highlighting the importance of considering DBP even when SBP is at target.
Compared to a DBP of 70 to <80 mmHg, lower and higher DBP was associated with a higher risk in patients achieving a SBP of 120 to <140 mmHg. Associations of DBP and PP to risk were similar notably at controlled SBP. These data suggest at optimal achieved SBP, risk is still defined by low or high DBP. These findings support guidelines which take DBP at optimal SBP control into consideration.
Böhm et al. (Thu,) studied this question.