Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study

OBJECTIVE: . DESIGN: Population based matched cohort study. SETTING: United Kingdom general practice (1995-2015). PARTICIPANTS: enrolled in the Health Improvement Network database: 64 141 had a penicillin allergy and 237 258 comparators matched on age, sex, and study entry time. MAIN OUTCOME MEASURES: . Secondary outcomes were use of β lactam antibiotics and β lactam alternative antibiotics. RESULTS: . CONCLUSIONS: among patients with a penicillin allergy label.