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Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to high costs and comorbidities. In the Third Edition of the International Classification of Headache Disorders, medication-overuse headache is recognized as a separate secondary entity next to mostly primary headache disorders, although many clinicians see the disease as a sole complication of primary headache disorders. In this review, we explore the historical background of medication-overuse headache, its epidemiology, phenomenology, pathophysiology and treatment options. The review explores relevant unanswered questions and summarizes the current debates in medication-overuse headache.
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Nicolas Vandenbussche
Domenico Laterza
Marco Lisicki
The Journal of Headache and Pain
SHILAP Revista de lepidopterología
King's College London
Wellcome Trust
University of Florence
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Vandenbussche et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69dd47e9fb7610310c1017fc — DOI: https://doi.org/10.1186/s10194-018-0875-x