Does intravenous thrombolysis have similar safety and efficacy in acute ischemic stroke patients on dual antiplatelet pretreatment compared to those with no antiplatelet pretreatment?
Acute ischemic stroke (AIS) patients eligible for intravenous thrombolysis (IVT)
Intravenous thrombolysis (IVT) in patients with a history of dual antiplatelet pretreatment
Intravenous thrombolysis (IVT) in patients with no antiplatelet pretreatment
Symptomatic intracranial hemorrhage (SICH), 3-month mortality rates, and functional outcomeshard clinical
Dual antiplatelet pretreatment history should not preclude the use of intravenous thrombolysis in eligible acute ischemic stroke patients.
Given that patients on dual antiplatelet pretreatment have similar SICH, 3-month mortality rates, and functional outcomes compared to patients with no antiplatelet pretreatment, dual antiplatelet pretreatment history should not be used as a reason to withhold IVT in otherwise eligible AIS patients. Ann Neurol 2018;83:89-97.
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Georgios Tsivgoulis
Aristeidis H. Katsanos
Dimitris Mavridis
Annals of Neurology
Karolinska Institutet
University of Aberdeen
Karolinska University Hospital
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Tsivgoulis et al. (Sun,) studied this question.
www.synapsesocial.com/papers/69a3048a5406085704ad98c1 — DOI: https://doi.org/10.1002/ana.25269
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