Does higher aortic stiffness relate to lower regional cerebral blood flow and cerebrovascular reactivity in cognitively normal older adults?
Central arterial stiffening may contribute to reductions in regional cerebral blood flow despite preserved cerebrovascular reserve capacity in older adults.
Greater aortic stiffening relates to lower regional CBF and higher CVR in cognitively normal older adults, especially among individuals with increased genetic predisposition for Alzheimer's disease. Central arterial stiffening may contribute to reductions in regional CBF despite preserved cerebrovascular reserve capacity.
Jefferson et al. (Tue,) studied this question.
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