Classifications in Brief: Tönnis Classification of Hip Osteoarthritis

History Hip osteoarthritis represents one of the most prevalent diseases affecting older adults, consistently ranking as one of the most common causes of functional disability in addition to carrying an immense socioeconomic burden 20. Published reports from the World Health Organization indicate that approximately 10% of men and 18% of women older than 60 years of age have symptomatic osteoarthritis 29. The level of functional disability can be highly variable, but it is estimated that approximately 80% of those with osteoarthritis have some limitation in movement and up to one-third of them can be considered “severely disabled.” It is an issue that will only increase in incidence over time, because it is estimated that the proportion of people older than 60 years of age will triple by 2050 29 Ackerman et al. 1 reviewed the lifetime risk of THA in males and females using registry data from five countries, finding the lifetime risk to be as high as one in seven women in Norway and one in 10 men in Finland by 2013; women consistently had higher lifetime risks of THA in their review. Epidemiologic studies evaluating hip osteoarthritis have demonstrated marked regional differences in the prevalence of the disease with Asians and Africans having a prevalence of 1.2% and 2.8% and North Americans and Europeans having a prevalence of 7.2% and 20.1%, respectively 12, 14. Numerous classification systems for hip osteoarthritis have been proposed, including the Tönnis classification, Croft classification 13 as well as the Kellgren-Lawrence classification previously reviewed in this section 17. The Tönnis classification originally rose from a series of research articles published in 1972 by Professor Dietrich Tönnis and his colleagues in Dortmund, Germany 5, 6. The aim of these studies was to develop a quantitative method to differentiate between normal and dysplastic juvenile hips. In their article entitled “A New Method for Roentgenologic Evaluation of the Hip Joint—the Hip Factor,” the authors assessed 817 adult hip radiographs (patient age 21-50 years, excluding patients who had undergone hip surgery) to develop a quantitative measurement for assessing hip dysplasia, ie, “the hip factor.” As part of the analysis, the authors grouped the patients into three separate grades of osteoarthritis based on the evaluation of a standard AP pelvis radiograph, which became the foundation of the classification scheme now bearing Tönnis’ name 6. Purpose Creating a new classification system for a particular pathology may be done for a number of reasons such as to improve effectiveness of communication among providers and/or researchers or even to dictate management of the pathology. Tönnis’ classification was initially created by him and his colleagues for the purposes of research to serve as a qualitative grade for severity of degenerative radiographic changes in adults 6 and was later used by Tönnis to correlate femoral/acetabular anteversion to severity of arthrosis 25. In these articles, nothing is said regarding the choice to create a new system in light of other systems having already been published at that time 16. As a qualitative analysis based off of a plain AP radiograph of the pelvis, the Tönnis classification offers the advantage of easy application to a clinic setting when compared with schemes requiring advanced imaging or quantitative measurements. Such characteristics make the scheme appealing for use in daily clinical practice as a potential tool to help subdivide surgical management. This warrants exploration into the reliability, and moreover the possibility in guiding management, of the Tönnis classification. Description of the Tönnis Classification The Tönnis classification, as originally described in 1972 by Busse et al. 6, consists of three progressive degrees of degenerative changes to the hip; it was later republished by Tönnis and Heinecke in 1999 25 with the addition of a Grade 0, or hip absent of arthrosis. Grade 1 indicates slight narrowing of the joint space, slight lipping at the joint margin, and slight sclerosis of the femoral head or acetabulum; Grade 2 indicates the presence of small bony cysts, further narrowing of the joint space, and moderate loss of femoral head sphericity; Grade 3 is the most severe and indicates large cysts, severe narrowing of the joint space, severe femoral head deformity, and avascular necrosis (Table 1).Table 1.: Tönnis grading scale of hip osteoarthritisIn addition to Tönnis’ classification, there have been a number of other well-described classification schemes for osteoarthritis; these include schemes published by Croft 13, Kellgren-Lawrence 16, the International Knee Documentation Committee 30, Fairbank 15, Altman et al. 3, and Ahlbäck 2. Of the aforementioned classifications, only the Kellgren-Lawrence and Croft classifications are applicable to the hip with the remainder describing the knee specifically. The Kellgren-Lawrence scale is a 5-point grading scale from 0 to 4;0 indicates no joint space narrowing nor reactive changes (no osteoarthritis OA); 1 indicates doubtful joint space narrowing with possible lipping osteophytes (doubtful OA); 2 indicates definite osteophytes with possible joint space narrowing (mild OA); 3 indicates moderate osteophytes with definite joint space narrowing, some sclerosis, and possible bony deformity (moderate OA); and 4 indicates progression to large osteophytes, severe sclerosis, and definite bone end deformity (severe OA). Croft et al. 13 devised a 6-point grading scale from 0 to 5; 0 indicates no radiographic abnormalities; 1 indicates only osteophytosis; 2 indicates joint space narrowing only; 3 indicates the presence of two out of the following: osteophytosis, joint space narrowing, presence of cysts, and subchondral sclerosis; 4 indicates three of the aforementioned criteria; and 5 indicates progression to femoral head deformity. Validation and Reliability The Tönnis classification is widely utilized by arthroplasty surgeons, arthroscopic surgeons, rheumatologists, radiologists, and physical therapists 4, 9, 10, 24. Despite its widespread use, the utility of the Tönnis classification has been a point of contention because of conflicting data regarding its reliability 7, 11, 18, 19, 23, 27, 28. In a 2008 study that included 63 patients who underwent a Bernese periacetabular osteotomy approximately 20 years prior, Steppacher et al. 23 evaluated the validity of the Tönnis classification using two orthopaedic surgeons to grade 50 pelvic radiographs on two separate occasions. They found substantial interobserver (κ = 0.74) and intraobserver reliability (κ = 0.73-0.76) using the standardized Landis and Koch benchmarks for agreement 18, 23. Clohisy et al. 11 evaluated reliability using 77 patients with femoroacetabular impingement, developmental dysplasia of the hip, or no hip pain and found slightly lower reliability than that of Steppacher et al. with moderate interobserver reliability (κ = 0.59) and intraobserver reliability (κ = 0.60). Their study used five hip specialists as well as a fellow to interpret the images. The authors attributed the lower agreement in their report compared with that of Steppacher to the inclusion of a control group. By contrast, a critical review of the Tönnis classification used three orthopaedic surgeons to classify the hip radiographs of 61 patients by Tönnis grade, divided into two cohorts (one included candidates for hip preservation surgery, whereas the control group consisted of patients without hip pain). This study found only slight to fair interobserver reliability (κ = 0.173-0.397) and fair intraobserver reliability (κ = 0.364-0.397). The most frequent cause of disagreement in this study involved differentiating Grade 0 from Grade 1 hips 28. Nepple et al. 19 also focused on younger patients with hip pain in a study evaluating 25 radiologic parameters of dysplasia and OA in 70 patients undergoing hip preservation surgery. Four hip specialists interpreted the radiographs. The average patient age was 31 years, and 55 of the 70 patients had femoroacetabular impingement with the remainder diagnosed with acetabular dysplasia. They found grading patients by the Tönnis classification had only fair interobserver reliability (κ = 0.22) and moderate intraobserver reliability (κ = 0.53). Like Valera et al. 28, the radiographs in this study were weighted heavily toward early arthritis with only 4.5% of patients graded as either Grade 2 or 3. In contrast, joint space width was found to have substantial inter- and intraobserver reliability (κ = 0.62 and 0.71, respectively) 19. Another reliability analysis by Carlisle et al. used five physicians of various disciplines and levels of training to evaluate 45 patients with developmental dysplasia of the hip, femoroacetabular impingement, or normal anatomy. One orthopaedic attending, two physiatry attendings, one orthopaedic fellow, and two orthopaedic residents interpreted the images. They found only slight interobserver agreement for Tönnis grade (κ = 0.17) but moderate intraobserver reproducibility (κ = 0.57) 7. In a study by Troelsen et al. 26, four observers (medical student, orthopaedic resident, orthopaedic attending, and radiology attending) reviewed 25 pelvic radiographs and subsequently their associated CT scans and graded them according to Tönnis’ classification. They found poor interobserver reliability with κ values ranging from -0.02 to 0.33; they found that interobserver agreement increased when Tönnis grade was dichotomized to Grades 0 to 1 and 2 to 3 (κ values 0.20-0.39) and that joint space width < 2 mm on plain radiographs was a more reliable marker of OA (κ values 0.40-0.46) 27. Limitations The development of the Tönnis classification system was based on studies that specifically focused on the hip. By extension, it most directly applies to a spheroidal (ie, ball-and-socket) synovial joint that is reinforced by the presence of a fibrocartilaginous lip (the acetabular labrum). Because other diarthrodial joints have different anatomy, and different roles in weightbearing and motion, the Tönnis grading system cannot be applied broadly to all joints. Studies on the classification seem to suggest less validity in its lower grades because studies with higher numbers of low-grade OA demonstrate lower validity for the Tönnis classification 11. This is especially important in one common application of the Tönnis classification, which is to help guide the decision of whether a patient may be a good candidate for hip preservation surgery, which is known to be less effective in patients who have even mild arthritis 31. In addition, because the Tönnis classification relies exclusively on radiographic findings, other variables that may play a role in the success of hip preservation surgery (such as articular cartilage health, three-dimensional femoroacetabular anatomy, labral integrity, among others) obviously are not considered under the Tönnis rubric, and adequate evaluation of those factors generally calls for advanced imaging. Ultimately, a major criticism of the Tönnis classification system is that it is subjective. The Tönnis classification has been criticized as being unclear in its terminology as well as for its failure of overlapping parameters 28. Five major radiographic findings are used in the classification: presence of sclerosis, joint space width, head sphericity, cyst size, and osteophyte formation, the latter of which is described as “lipping at the joint margins.” None of these parameters includes quantitative definitions. For example, Tönnis Grade 2 arthritis includes “small” subchondral cysts, and Grade 3 is defined by “large” cysts, but there are no sizes designated in the original article. In addition, Tönnis’ original article does not help the user decide which grade to use if findings from two different grades are present on one radiograph. For example, if a patient has moderate loss of sphericity of the femoral head (a Tönnis Grade 2 finding) alongside only slight narrowing of the joint (a Grade 1 finding)—such as might occur in a patient with early Legg-Calvé-Perthes disease—the Tönnis classification is unclear about whether this would be a patient with Grade 1 or Grade 2 arthritis. Instead, the classification assumes a stepwise progression in which all parameters radiographically worsen over time equally in accordance with the described classification, which is not always the case. As noted by Valera et al. 28, although sphericity of the femoral head is one of the more reliably reproducible parameters used by Tönnis, it could easily lead to confusion in grading in patients with nondegenerative cam deformity and no radiographic findings of OA. Conclusions Although the Tönnis classification has limitations, it remains a simple system that provides a qualitative description of commonly obtained radiographic imaging of the hip and continues to be frequently used in clinical practice as well as research. It relies on the visual assessment of an AP pelvis radiograph and does not require additional time or resources to make digital or manual measurements of the radiographs. The subjective nature of the classification and the lack of consensus on its reliability (particularly at early stages of hip arthritis, where the user wishes to distinguish Grade 0 from Grade 1 11, 19, 28) make it difficult to recommend its widespread use, particularly given that alternative classification schemes including the Kellgren-Lawrence and Croft systems have been demonstrated in studies to be more reliable measures. In a reliability study by Reijman et al. 22, the Kellgren-Lawrence system had higher interobserver reliability (κ = 0.68) than Croft’s (κ = 0.52) and demonstrated both a stronger association with clinical symptoms of hip OA as well as being predictive of the eventual need for hip replacement. Similarly, additional studies have demonstrated support for the validity of the Kellgren-Lawrence scheme in particular 21. Several studies have found that patients with higher grade Tönnis grades who undergo hip preservation surgery have poorer patient-reported outcome scores and are more likely to undergo premature conversion to THA 8. This suggests that despite the problems of reliability, the Tönnis classification may be used to good effect as a tool of communication, prognosis, and research in the right circumstances. In our opinion, the Tönnis classification is a straightforward qualitative description of a stepwise pattern of hip OA but has limited utility in the research setting. Its reliability has not consistently demonstrated superiority over other classification systems. Ultimately, without stronger evidence supporting its reliability or validity, it cannot be recommended as a tool with which to routinely guide management and treatment options.