Women demonstrated significantly higher intrinsic mitochondrial respiration and lower mitochondrial oxygen affinity (p50mito 0.22 vs 0.07 kPa) compared to men matched for maximal oxygen consumption.
Cross-Sectional (n=28)
No
Women demonstrate superior intrinsic mitochondrial respiration and higher proton leak compared to men matched for aerobic capacity, highlighting significant sex-based differences in skeletal muscle mitochondrial function.
Absolute Event Rate: 0.22% vs 0.07%
p-value: p=<0.05
exist between women and men. These findings may represent an adaptation in the oxygen cascade in women to optimize muscle oxygen uptake to compensate for a lower oxygen delivery during exercise.
Cardinale et al. (Fri,) conducted a cross-sectional in Healthy active individuals (n=28). Female sex vs. Male sex (matched for VO2max) was evaluated on Mitochondrial oxygen affinity (p50mito) with complex I+II substrates (kPa) (p=<0.05). Women demonstrated significantly higher intrinsic mitochondrial respiration and lower mitochondrial oxygen affinity (p50mito 0.22 vs 0.07 kPa) compared to men matched for maximal oxygen consumption.
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