Radiation therapy initiates and accelerates atherosclerosis, leading to vascular events like stroke and coronary artery disease, potentially driven by a systemic inflammatory state.
Radiation therapy can initiate and accelerate atherosclerosis through systemic inflammation, leading to long-term vascular complications such as stroke and coronary artery disease.
In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by vascular endothelial injury. Radiation both initiates and accelerates atherosclerosis, leading to vascular events like stroke, coronary artery disease, and peripheral artery disease. Increased levels of proinflammatory cytokines in the blood of long-term survivors of the atomic bomb suggest that radiation evokes a systemic inflammatory state responsible for chronic vascular side effects. In this review, the authors offer an overview of potential mechanisms implicated in radiation-induced vascular injury.
Venkatesulu et al. (Wed,) conducted a review in Radiation-induced vascular injury. Radiation therapy was evaluated. Radiation therapy initiates and accelerates atherosclerosis, leading to vascular events like stroke and coronary artery disease, potentially driven by a systemic inflammatory state.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: