The APOE ε44 genotype significantly increased the risk of all dementia compared to the ε33 genotype (HR 5.77), with absolute 10-year risk reaching up to 38% in women aged 80 years and older.
Cohort (n=104,537)
Does APOE ɛ44 genotype increase the risk of Alzheimer disease and all dementia in the general population?
Age, sex, and APOE genotype robustly identify high-risk groups for Alzheimer disease and all dementia, with ɛ44 carriers having a nearly 6-fold increased risk compared to ɛ33 carriers.
Hazard Ratio: 5.77 (95% CI 4.89–6.81)
p-value: p=<0.001
BACKGROUND: Dementia is a major cause of disability, and risk-factor reduction may have the potential to delay or prevent the disease. Our aim was to determine the absolute 10-year risk of dementia, by age, sex and apolipoprotein E (APOE) genotype. METHODS: We obtained data from the Copenhagen General Population Study (from 2003 to 2014) and the Copenhagen City Heart Study (from 1991 to 1994 and 2001 to 2003). Participants underwent a questionnaire, physical examination and blood sampling at baseline. Diagnoses of dementia and cerebrovascular disease were obtained from the Danish National Patient Registry up to Nov. 10, 2014. RESULTS: Among 104 537 individuals, the absolute 10-year risk of Alzheimer disease in 3017 women and men who were carriers of the APOE ɛ44 genotype was, respectively, 7% and 6% at age 60–69 years, 16% and 12% at age 70–79 years, and 24% and 19% at age 80 years and older. Corresponding values for all dementia were 10% and 8%, 22% and 19%, and 38% and 33%, respectively. Adjusted hazard ratios (HRs) for all dementia increased by genotype, from genotype ɛ22 to ɛ32 to ɛ33 to ɛ42 to ɛ43 to ɛ44 (p for trend INTERPRETATION: Age, sex and APOE genotype robustly identify high-risk groups for Alzheimer disease and all dementia. These groups can potentially be targeted for preventive interventions.
Rasmussen et al. (Mon,) conducted a cohort in Dementia (n=104,537). APOE ε44 genotype vs. APOE ε33 genotype was evaluated on All dementia (HR 5.77, 95% CI 4.89-6.81, p=<0.001). The APOE ε44 genotype significantly increased the risk of all dementia compared to the ε33 genotype (HR 5.77), with absolute 10-year risk reaching up to 38% in women aged 80 years and older.