A standardized fast-food meal significantly reduced peripheral brachial artery flow-mediated dilation at 2 hours (P=0.01) but did not affect cerebral vasomotor reactivity in healthy young men.
Does a standardized fast-food meal reduce cerebral vascular hypercapnic reactivity and peripheral artery endothelial function in healthy young men?
A single fast-food meal acutely impairs peripheral endothelial function but does not affect cerebral vascular reactivity in healthy young men.
Consumption of a representative fast-food meal (FFMeal) acutely impairs peripheral conduit artery vascular function; however, the effect on cerebral vascular function remains unknown. This study tested the hypothesis that a FFMeal would impair cerebral vascular function as indexed by an attenuated increase in cerebral vascular conductance (CVCI) in the middle cerebral artery (MCA) during a hypercapnic challenge. Ten healthy men (age: 24 AE 3 years, BMI: 24.3 AE 3.8 kg/m 2 ) were studied under two conditions; a standardized FFMeal (990 kcals, 50% fat, 36% carbohydrate, 14% protein, and 2120 mg sodium) and a fasting control condition. Basal hemodynamics, cerebral vasomotor reactivity (CVMR), and brachial artery flow-mediated dilation (BA FMD) were completed after an overnight fast (Pre) and again 2 h and 4 h later both days. To assess CVMR, subjects rebreathed from a 5-L bag while MCA velocity (MCAV mean ) was measured using transcranial Doppler (TCD) ultrasound and converted into CVCI (MCAV mean /mean arterial pressure). Peripheral artery endothelial function was assessed via BA FMD following a standard 5-min occlusion protocol. As expected, BA FMD was reduced at 2 h (Pre: 6.6 AE 1.7% vs. 5.2 AE 1.8%, P = 0.01). However, despite significant impairment in BA FMD, neither peak CVCI %baseline nor CVMR was affected by the FFMeal (Control-Pre: 1.9 AE 1.1, 2 h: 2.1 AE 1.1, 4 h: 1.7 AE 1.1 CVCI%P ET CO 2 1 vs. FFMeal-Pre: 2.1 AE 1.1, 2 h: 2.2 AE 0.7, 4 h:
Patik et al. (Sat,) conducted a other in Healthy (n=10). Standardized fast-food meal (FFMeal) vs. Fasting control was evaluated on Cerebral vascular conductance (CVCI) in the middle cerebral artery during a hypercapnic challenge. A standardized fast-food meal significantly reduced peripheral brachial artery flow-mediated dilation at 2 hours (P=0.01) but did not affect cerebral vasomotor reactivity in healthy young men.