The proposed 3D free-breathing native myocardial T1 mapping sequence at 3 T yielded homogeneous whole-heart T1 maps with a significantly lower septal coefficient of variation compared to 2D SASHA.
Does a 3D free-breathing native myocardial T1 mapping sequence at 3 T provide accurate and homogeneous T1 measurements in healthy adults and phantoms?
Free-breathing 3D native T1 mapping at 3 T is feasible and provides homogeneous T1 maps, offering a potential alternative for myocardial assessment when breath-holding is unfeasible or larger coverage is needed.
Absolute Event Rate: 2.1% vs 3.9%
p-value: p=0.0007
This study demonstrates a three-dimensional (3D) free-breathing native myocardial T1 mapping sequence at 3 T. The proposed sequence acquires three differently T1-weighted volumes. The first two volumes receive a saturation pre-pulse with different recovery time. The third volume is acquired without magnetization preparation and after a significant recovery time. Respiratory navigator gating and volume-interleaved acquisition are adopted to mitigate misregistration. The proposed sequence was validated through simulation, phantom experiments and in vivo experiments in 12 healthy adult subjects. In phantoms, good agreement on T1 measurement was achieved between the proposed sequence and the reference inversion recovery spin echo sequence (R2 = 0.99). Homogeneous 3D T1 maps were obtained from healthy adult subjects, with a T1 value of 1476 ± 53 ms and a coefficient of variation (CV) of 6.1 ± 1.4% over the whole left-ventricular myocardium. The averaged septal T1 was 1512 ± 60 ms with a CV of 2.1 ± 0.5%. Free-breathing 3D native T1 mapping at 3 T is feasible and may be applicable in myocardial assessment. The proposed 3D T1 mapping sequence is suitable for applications in which larger coverage is desired beyond that available with single-shot parametric mapping, or breath-holding is unfeasible.
Guo et al. (Thu,) conducted a other in Healthy (n=12). 3D free-breathing saturation-based T1 mapping sequence vs. 2D SASHA was evaluated on Septal T1 coefficient of variation (CV) (p=0.0007). The proposed 3D free-breathing native myocardial T1 mapping sequence at 3 T yielded homogeneous whole-heart T1 maps with a significantly lower septal coefficient of variation compared to 2D SASHA.