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More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis, induce inflammation and control the immune response. Cytokines are secreted glycoproteins that act as intercellular messengers, inducing proliferation, differentiation, growth, or apoptosis of their target cells. They act by binding to specific receptors on the surface of target cells and switching on a phosphotyrosine-based intracellular signaling cascade initiated by kinases then propagated and effected by SH2 domain-containing transcription factors. As cytokine signaling is proliferative and often inflammatory, it is tightly regulated in terms of both amplitude and duration. Here we review molecular details of the cytokine-induced signaling cascade and describe the architectures of the proteins involved, including the receptors, kinases, and transcription factors that initiate and propagate signaling and the regulatory proteins that control it.
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Rhiannon Morris
Nadia J. Kershaw
Jeffrey J. Babon
Protein Science
The University of Melbourne
Walter and Eliza Hall Institute of Medical Research
The Royal Melbourne Hospital
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Morris et al. (Sat,) studied this question.
www.synapsesocial.com/papers/69da1d80387cf7069868605b — DOI: https://doi.org/10.1002/pro.3519