Five ACE2 gene single-nucleotide polymorphisms were significantly associated with essential hypertension in female participants, while no locus was linked in males.
Case-Control (n=1,980)
Are ACE2 gene polymorphisms and enzymatic activity associated with essential hypertension in the northeastern Chinese Han population?
Specific ACE2 gene polymorphisms are significantly associated with essential hypertension in females of the northeastern Chinese Han population, and ACE2 activity correlates with clinical parameters.
Angiotensin-converting enzyme 2 (ACE2) plays an important role in the development of essential hypertension (EH). The aim of this study was to investigate the relationship of ACE2 gene polymorphisms and enzymatic activity with EH in the northeastern Chinese Han population. 34 single-nucleotide polymorphism (SNP) loci of ACE2 were detected in 1024 EH patients and 956 normotensive (NT) controls by Sequenom Mass-ARRAY RS1000. Five SNPs (rs1514283, rs4646155, rs4646176, rs2285666, and rs879922) in ACE2 gene were determined to significantly associate with EH in female participants, while no SNP locus was linked to male group. Specifically, it was the first time to report that rs4646155 was significantly associated with EH in females. Furthermore, the correlation between ACE2 activity and clinical parameters were performed by Pearson correlation analysis in EH patients. We found that the ACE2 activity level was negatively correlated with body mass index (BMI), DBP, and pulse pressure, and significantly positively with ACE2 concentration, blood glucose and estrogen level in female EH patients. These results demonstrated that the genetic variants of ACE2 played vital roles in the development of EH. And the serum ACE2 activity can predict the development of cardiac dysfunction in EH patients.
Zhang et al. (Mon,) conducted a case-control in Essential hypertension (n=1,980). ACE2 gene polymorphisms vs. Normotensive controls was evaluated on Association with essential hypertension. Five ACE2 gene single-nucleotide polymorphisms were significantly associated with essential hypertension in female participants, while no locus was linked in males.