October 16, 2018

KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition

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Abstract

Our findings suggest that signaling adaptation can in some instances limit the efficacy of ARS1620 but combination with PI3K inhibitors can overcome this resistance.

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Authors

Sandra Misale

Jackson P. Fatherree

Eliane Cortez

Journals

Clinical Cancer Research

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Institutions

Harvard University

Massachusetts General Hospital

Fujikura (United States)

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KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition

Key Points

Abstract

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Discussion

Authors

Journals

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References and Citations

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