Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2)

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/<i>neu</i>Oncogene1987 · 11,763 citations
2. 2Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing2013 · 39 citations
3. 3<i>HER2</i> missense mutations have distinct effects on oncogenic signaling and migration2015 · 84 citations
4. 4HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer2017 · 130 citations
5. 5HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer2014 · 40 citations