African American patients with T2D had higher risks of heart failure and ESRD than White patients, with African American men also having a lower risk of CHD (HR 0.88; 95% CI 0.83-0.94).
Cohort (n=67,544)
Yes
Does the incidence of major diabetic complications differ by race and sex between African Americans and Whites with type 2 diabetes?
African Americans with type 2 diabetes experience higher rates of heart failure and ESRD compared to Whites, with sex-specific differences in stroke and CHD risk.
BACKGROUND: Studies on racial differences in diabetic complications are very limited. The aim of this study was to investigate the race and sex differences in diabetic complications between African Americans and Whites with type 2 diabetes (T2D) in Louisiana. METHODS: A prospective cohort study was performed of 27 113 African Americans and 40 431 Whites with T2D who were 35 to 95 years of age from three healthcare systems located in south Louisiana. Four major diabetic complications were assessed: coronary heart disease (CHD), heart failure, stroke, and end-stage renal disease (ESRD). RESULTS: The age- and sex-adjusted incident rates per 1000 person-years and 95% confidence intervals (CI) for CHD, heart failure, stroke, and ESRD for African Americans with diabetes were 43.1 (95% CI 41.6-44.6), 36.6 (95% CI 35.2-37.9), 29.6 (95% CI 28.4-30.8), and 38.3 (95% CI 36.9-39.7), respectively. Cox regression models showed that African American women had a higher risk than White women for heart failure (hazard ratio (HR) 1.26; 95% CI 1.18-1.34), stroke (HR 1.15; 95% CI 1.08-1.22), and ESRD (HR 1.32; 95% CI 1.24-1.40), whereas African American men had higher risks than White men for heart failure (HR 1.33; 95% CI 1.25-1.43) and ESRD (HR 1.47; 95% CI 1.37-1.57) but a lower risk of CHD (HR 0.88; 95% CI 0.83-0.94). CONCLUSIONS: The incidence of major diabetic complications varied among difference race and sex groups. More race- or sex-specific studies on complications in patients with diabetes are needed to see whether incident rates are changing over time.
Shen et al. (Sat,) conducted a cohort in Type 2 diabetes (n=67,544). African American race vs. White race was evaluated on Coronary heart disease (CHD), heart failure, stroke, and end-stage renal disease (ESRD). African American patients with T2D had higher risks of heart failure and ESRD than White patients, with African American men also having a lower risk of CHD (HR 0.88; 95% CI 0.83-0.94).