What is the clinical evidence from this study?

Study design: Observational. Population: Nonvalvular atrial fibrillation (n=165). Primary outcome: Etiological association of nonvalvular atrial fibrillation.

November 22, 2018Open Access

Nonvalvular atrial fibrillation: a study of epidemiology, demography and clinicoetiological profile in Central India

MJMayank JainSawai ManSingh Medical College and Hospital PKPriyanka KiyawatMahatma Gandhi Memorial Medical College

Key Result

Systemic hypertension was the most common etiological association (70.9%) in patients with nonvalvular atrial fibrillation, with advanced age and male gender identified as significant risk factors.

Study Design

Type

Observational (n=165)

Structured PICO

Population

165 patients aged ≥18 years with electrocardiographic documentation of nonvalvular atrial fibrillation (chronic or paroxysmal) during the preceding 6 months. Mean age 64.71, 56.36% male.

Outcome

Epidemiology, demography, and clinicoetiological profile

In Central India, nonvalvular atrial fibrillation is most commonly associated with systemic hypertension, advanced age, and male gender.

Limitations

The incident cases of AF events were relatively small, which might have reduced the power to detect the risk of AF.
The study reports natural history amongst the AF population for two years retrospectively, which may be inadequate to judge the associated complications, morbidity, and mortality.

Abstract

Background: Atrial fibrillation (AF) is the most common sustained disorder of cardiac rhythm. To study the epidemiology, demography and clinicoetiological profile of nonvalvular atrial fibrillation, such studies are sparse in India.Methods: One hundred sixty-five patients of nonvalvular atrial fibrillation were enrolled prospectively in the study during the period February 2017 to May 2018. Patients with an electrocardiographic documentation of atrial fibrillation, either chronic or paroxysmal were enrolled in the study. Patients underwent thorough physical examination, routine laboratory testing, and other relevant investigations to assess the underlying etiology. Baseline characteristics of all the patients’ viz. type of AF, primary etiological diagnosis, and baseline clinical parameters were noted. Statistical analysis was done using percentage analysis.Results: A total of 165 patients were enrolled in the study. The vast majority of patients were elderly; with the majority being in the 56-65years age group (45.45%). AF was more common in men (56.3%). Systemic hypertension was the most common etiological association (80%).Conclusions: Present study found that advanced age and male gender are significant risk factors for AF. Systemic hypertension is the most common etiological association with nonvalvular AF.

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