Is mild-to-moderate hypertriglyceridemia associated with a higher risk of acute pancreatitis, and is this mediated by low-grade inflammation?
Mild-to-moderate hypertriglyceridemia increases the risk of acute pancreatitis, potentially mediated by low-grade inflammation.
BACKGROUND: ) the association between mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis depends on low-grade inflammation. METHODS: From the Copenhagen General Population Study and the Copenhagen City Heart Study, 117865 men and women 20-100+ years of age with measurements of nonfasting plasma triglycerides at baseline were followed prospectively for development of acute pancreatitis. RESULTS: = 0.41 for leukocytes). CONCLUSIONS: Mild-to-moderate hypertriglyceridemia is associated with low-grade inflammation and higher risk of acute pancreatitis. The association between mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis is possibly partly mediated by low-grade inflammation.
Hansen et al. (Wed,) studied this question.
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