Is a loss-of-function variant in the TTN gene associated with early-onset atrial fibrillation?
A loss-of-function variant in the TTN gene is significantly associated with early-onset atrial fibrillation, though causality remains to be established.
In a case-control study, there was a statistically significant association between an LOF variant in the TTN gene and early-onset AF, with the variant present in a small percentage of participants with early-onset AF (the case group). Further research is necessary to understand whether this is a causal relationship.
Choi et al. (Tue,) studied this question.