Diabetes mellitus conferred a greater risk of 1-year death or heart failure hospitalization in women (HR 1.79; 95% CI 1.24-2.60) than in men (HR 1.32; 95% CI 1.12-1.56; Pinteraction=0.005).
Observational (n=5,255)
Sí
Does diabetes mellitus differentially impact clinical characteristics, quality of life, and 1-year outcomes in men versus women with HFrEF?
In Asian patients with HFrEF, diabetes confers a significantly greater risk of adverse outcomes, chronic kidney disease, and concentric left ventricular geometry in women compared to men.
Estimación del efecto: HR 1.79 (women), HR 1.32 (men) (95% CI 1.24-2.60 (women), 1.12-1.56 (men))
valor p: p=0.005 (interaction)
Abstract Aims To examine sex differences in clinical characteristics, echocardiographic features, quality of life and 1-year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM). Methods and results Utilizing the Asian Sudden Cardiac Death in HF (ASIAN-HF) registry, 5255 patients (mean age 59.6 ± 13.1, 78% men) with symptomatic HF with reduced ejection fraction (HFrEF) were stratified by DM status to address the research aims. Despite similar prevalence of DM between Asian men (43%) and women (42%), the odds of DM increased at lower body mass index in women vs. men (≥ 23 vs. ≥ 27.5 kg/m2, Pinteraction = 0.014). DM was more strongly related to chronic kidney disease in women vs. men adjusted odds ratio (OR) 1.85, 95% confidence interval (CI) 1.33–2.57 vs. OR 1.32, 95% CI 1.11–1.56, Pinteraction = 0.009. Sex also modified the relationship between DM and left ventricular geometry (Pinteraction = 0.003), whereby DM was associated with a more concentric left ventricular geometry in women than men. Women had lower quality of life than men (P 0.001), in both DM and non-DM groups. DM was associated with worse composite outcomes at 1 year in women vs. men [hazard ratio (HR) 1.79, 95% CI 1.24–2.60 vs. HR 1.32, 95% CI 1.12–1.56; Pinteraction = 0.005). Conclusions Asian women with HFrEF were more likely to have DM despite a lean body mass index, a greater burden of chronic kidney disease and more concentric left ventricular geometry, compared to men. Furthermore, DM confers worse quality of life, irrespective of sex, and a greater risk of adverse outcomes in women than men. These data underscore the need for sex-specific approaches to diabetes in patients with HF.
Chandramouli et al. (Mon,) conducted a observational in Heart failure with reduced ejection fraction (HFrEF) (n=5,255). Diabetes mellitus vs. No diabetes mellitus was evaluated on 1-year death or heart failure (HF) hospitalization (HR 1.79 (women), HR 1.32 (men), 95% CI 1.24-2.60 (women), 1.12-1.56 (men), p=0.005 (interaction)). Diabetes mellitus conferred a greater risk of 1-year death or heart failure hospitalization in women (HR 1.79; 95% CI 1.24-2.60) than in men (HR 1.32; 95% CI 1.12-1.56; Pinteraction=0.005).