The follicular phase of the menstrual cycle was associated with prolonged QTc (0.43 vs 0.39) and QTd (67 vs 58) compared to the luteal phase in eumenorrhic females.
Cross-Sectional (n=30)
Does the phase of the menstrual cycle alter cardiac ventricular repolarization in eumenorrhic females?
Cardiac ventricular repolarization, characterized by QTc and QTd, is prolonged during the follicular phase compared to the luteal phase in eumenorrhic females.
Absolute Event Rate: 0.43% vs 0.39%
Introduction: The gonadal hormones accompanying the menstrual cycle in a female affect the ventricular repolarization regionally in the cardiac muscle as well as affects its recovery time both of which are QTc AND QTd measured conventionally using a non-invasive ECG. A prolonged QTc and QTd are predictors of cardiac morbidity and mortality. Aim: The aim of the present study was to examine whether the cardiac ventricular repolarization is altered during different phases of menstrual cycle by the endogenous gonadal hormones. Materials and Methods: Thirty eumenorrhic females were examined using 12 lead ECG during the follicular and luteal phases of menstrual cycle. Statistical Analysis: Data was analysed statistically using student’s paired t-test. Results: It was observed that the heart rate in follicular phase was (78.8 ±7.48) while in luteal (84 ± 8.17), R-R interval in follicular was (82±5.89) while in luteal phase was (77±3.69) QT interval in follicular was (0.39±0.09) while in luteal phase was (0.33±0.08), QTc in follicular was (0.43±0.03) while in luteal phase was (0.39±0.03), QTd in follicular was (67 ± 2.30) while in luteal phase was (58±4.08). Conclusion: We hence elucidate interactions between the sex steroids and cardiac conduction dynamics which is characterized by a prolonged QTc and QTd during the follicular phase. Keywords: Endogenous, Gonadal, Menstrual cycle, Repolarization
Anand et al. (2018) conducted a cross-sectional in Eumenorrhic females (n=30). Follicular phase vs. Luteal phase was evaluated on QTc. The follicular phase of the menstrual cycle was associated with prolonged QTc (0.43 vs 0.39) and QTd (67 vs 58) compared to the luteal phase in eumenorrhic females.