Running a 24-h ultra-marathon significantly increased hsCRP and H-FABP (p<0.001) and CK-MB and cTnT (p<0.05) compared to pre-race, and altered post-race diastolic function (p<0.01).
Observational (n=14)
Does a 24-h ultra-marathon alter cardiac biomarkers and cardiovascular function in male ultra-marathoners?
A 24-h ultra-marathon significantly stimulates specific cardiac biomarkers and alters diastolic function, suggesting exercise duration and intensity cause risk of cardiac stress.
p-value: p=<0.001
The aim of the present study was to examine the acute effect of an ultra-endurance performance on N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac specific troponin T (cTnT), creatinine kinase-myocardial band (CK-MB), high sensitive C-reactive protein (hsCRP), ischemia modified albumin (IMA), heart-type fatty acid binding protein (H-FABP) and cardiovascular function. Cardiac biomarkers were evaluated in 14 male ultra-marathoners (age 40 ± 12 years) during a 24 h ultra-marathon at five points (i.e., Pre-race; Marathon, 12-h run, 24-h run, and 48-h post-race). All subjects underwent baseline echocardiography assessment at least 10 days prior to the ultra-marathon and 48 h post-race. The average distance covered during the race was 149.4 ± 33.0 km. Running the ultra-marathon led to a progressive increase in hsCRP and H-FABP concentrations (p < 0.001). CK-MB and cTnT levels were higher after a 24-h run compared to pre-race (p < 0.05). Diastolic function was altered post-race characterized by a reduction in peak early to late diastolic filling (p < 0.01). Running an ultra-marathon significantly stimulates specific cardiac biomarkers; however, the dynamic of secretion of biomarkers linked to myocardium ischemia were differentially regulated during the ultra-marathon race. It is suggested that both exercise duration and intensity play a crucial role in cardiovascular adaptive mechanisms and cause risk of cardiac stress in ultra-marathoners.
Żebrowska et al. (Tue,) conducted a observational in Ultra-marathoners (n=14). 24-h ultra-marathon vs. Pre-race baseline was evaluated on Acute changes in cardiac biomarkers (hsCRP, H-FABP, CK-MB, cTnT) and cardiovascular function (p=<0.001). Running a 24-h ultra-marathon significantly increased hsCRP and H-FABP (p<0.001) and CK-MB and cTnT (p<0.05) compared to pre-race, and altered post-race diastolic function (p<0.01).
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