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Background: Surfactants are widely used across the globe both in industrial and consumer products. The n-octanol/ water partition ratio or coefficient (log K ow ) and n-octanol/water distribution coefficient (log D) are key parameters in environmental risk assessment of chemicals as they are often used to estimate the environmental fate and bioavailability and thus exposure and toxicity of a compound. Determining log K ow data for surfactants is a technical challenge due to their amphiphilic properties. Currently several existing experimental OECD methods (e.g. slow-stirring, HPLC, solubility ratio) and QSPR models are available for log K ow /D measurement or prediction. However, there are concerns that these methods have not been fully validated for surfactants and may not be applicable due to the specific phase behaviour of surfactants.
Hodges et al. (Wed,) studied this question.