High-intensity intermittent exercise training induced beneficial remodeling of left ventricular cardiomyocytes in spontaneously hypertensive rats, without deleterious effects.
Does high-intensity intermittent exercise training improve cardiomyocyte remodeling in spontaneously hypertensive rats compared to moderate continuous training or sedentary control?
High-intensity intermittent exercise training induces beneficial remodeling of left ventricular cardiomyocytes in hypertensive rats, supporting its safety and potential utility in hypertension rehabilitation.
Exercise training offers possible nonpharmacological therapy for cardiovascular diseases including hypertension. High-intensity intermittent exercise (HIIE) training has been shown to have as much or even more beneficial cardiovascular effect in patients with cardiovascular diseases than moderate-intensity continuous exercise (CMIE) training. The aim of this study was to investigate the effects of the two types of training on cardiac remodeling of spontaneously hypertensive rats (SHR) induced by hypertension. Eight-week-old male SHR and normotensive Wistar-Kyoto rats (WKY) were divided into four groups: normotensive and hypertensive control (WKY and SHR-C) and hypertensive trained with CMIE (SHR-T CMIE) or HIIE (SHR-T HIIE). After 8 wk of training or inactivity, maximal running speed (MRS), arterial pressure, and heart weight were all assessed. CMIE or HIIE protocols not only increased final MRS and left ventricular weight/body weight ratio but also reduced mean arterial pressure compared with sedentary group. Then, left ventricular tissue was enzymatically dissociated, and isolated cardiomyocytes were used to highlight the changes induced by physical activity at morphological, mechanical, and molecular levels. Both types of training induced restoration of transverse tubule regularity, decrease in spark site density, and reduction in half-relaxation time of calcium transients. HIIE training, in particular, decreased spark amplitude and width, and increased cardiomyocyte contractility and the expression of sarco(endo)plasmic reticulum Ca 2+ -ATPase and phospholamban phosphorylated on serine 16. NEW & NOTEWORTHY High-intensity intermittent exercise training induces beneficial remodeling of the left ventricular cardiomyocytes of spontaneously hypertensive rats at the morphological, mechanical, and molecular levels. Results also confirm, at the cellular level, that this type of training, as it appears not to be deleterious, could be applied in rehabilitation of hypertensive patients.
Krzesiak et al. (2019) studied Hypertension. High-intensity intermittent exercise (HIIE) vs. Moderate-intensity continuous exercise (CMIE) and sedentary control was evaluated on Cardiac remodeling (morphological, mechanical, and molecular levels). High-intensity intermittent exercise training induced beneficial remodeling of left ventricular cardiomyocytes in spontaneously hypertensive rats, without deleterious effects.